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However, excessive excitatory action of glutamate may cause excitotoxic neuronal damage as a result of a sustained influx of extracellular calcium ions (Ca 2+ ) [109, 110]

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Tamaño:5,5 ml / 0,5 g

Interleukin-1 (IL-1) is a major pro-inflammatory cytokine that induces matrix degradation in intervertebral discs (IVDs) by upregulating matrix metalloproteinases (MMPs) and aggrecanases, leading to extracellular matrix (ECM) breakdown and disc degeneration [22]